Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors

戊巴比妥 非快速眼动睡眠 药理学 化学 5-羟色胺能 睡眠(系统调用) 受体 医学 心理学 血清素 神经科学 眼球运动 生物化学 计算机科学 操作系统
作者
Lulu Wang,X.-Y. Cui,S.-Y. Cui,Jiexin Cao,Jie Zhang,Yonghe Zhang,Qianqian Zhang,Yifei Bai,Ye Zhao
出处
期刊:Phytomedicine [Elsevier BV]
卷期号:17 (6): 404-409 被引量:99
标识
DOI:10.1016/j.phymed.2010.01.014
摘要

Previous results have suggested that spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, potentiates pentobarbital-induced sleep via the serotonergic system. The present study investigated whether spinosin potentiates pentobarbital-induced sleep via serotonin-1A (5-hydroxytryptamine, 5-HT1A) receptors. The results demonstrated that spinosin significantly augmented pentobarbital (35 mg/kg, i.p.)-induced sleep in rats, reflected by reduced sleep latency and increased total sleep time, non-rapid eye movement (NREM) sleep time, and REM sleep time. With regard to NREM sleep duration, spinosin mainly increased slow-wave sleep (SWS). Additionally, spinosin (15 mg/kg, i.g.) significantly antagonized 5-HT1A agonist 8-OH-DPAT (0.1 mg/kg, i.p.)-induced reductions in total sleep time, NREM sleep, REM sleep, and SWS in pentobarbital-treated rats. These results suggest that spinosin may be an antagonist at postsynaptic 5-HT1A receptors because these effects of 8-OH-DPAT were considered to be mediated via postsynaptic 5-HT1A receptors. Moreover, co-administration of spinosin and the 5-HT1A antagonist 4-iodo-N-{2-[4-(methoxyphenyl)-1-piperazinyl]ethyl}-N-2-pyridinylbenzamide (p-MPPI), at doses that are ineffective when administered alone (spinosin 5 mg/kg, p-MPPI 1 mg/kg), had significant augmentative effects on pentobarbital-induced sleep, reflected by reduced sleep latency and increased total sleep time, NREM sleep, and REM sleep. In contrast to the attenuating effects of p-MPPI on REM sleep via presynaptic 5-HT1A autoreceptors, 15 mg/kg spinosin significantly increased REM sleep. These results suggest that the effect of spinosin on REM sleep in pentobarbital-treated rats may be related to postsynaptic 5-HT1A receptors.
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