肠化生
癌症
慢性胃炎
幽门螺杆菌
胃粘膜
病理
生物
胃炎
萎缩性胃炎
癌变
化生
发病机制
基因表达谱
DNA微阵列
癌症研究
基因
基因表达
胃
内科学
医学
遗传学
作者
Alex Boussioutas,Hong Li,Jia Liu,Paul Waring,H. Miles Prince,Andrew Holloway,Douglas Taupin,Kylie L. Gorringe,Izhak Haviv,Paul Desmond,David D.L. Bowtell
出处
期刊:PubMed
日期:2003-05-15
卷期号:63 (10): 2569-77
被引量:212
摘要
Current epidemiological evidence supports a pathogenetic model of gastric cancer involving intermediate stages that include chronic gastritis and intestinal metaplasia. This study explores the molecular features of gastric cancer and premalignant stages using DNA microarray-based gene expression profiling and relates these findings to clinical, pathological, and ethnic parameters. A total of 124 tumor and adjacent mucosa samples were analyzed using spotted cDNA microarrays containing 9381 nonredundant gene elements. Tumor specimens were diffuse, intestinal, or mixed gastric cancer and adjacent mucosa, which generally displayed signs of chronic gastritis or intestinal metaplasia. Expression patterns could be discerned that readily defined premalignant and tumor subtypes. Chronic gastritis exhibits a pronounced mitochondrial gene expression signature, which may be linked to Helicobacter pylori pathogenesis. Intestinal metaplasia was associated with increased expression of many intestinal differentiation genes, many of which were not overexpressed in tumors. Samples were obtained from 91 Australian and 33 Chinese patients to explore potential variation in gene expression between these populations. Despite differences in the incidence, and potentially the etiology, of gastric cancer between these ethnic groups, we found the tumors to be molecularly similar. The identification of molecular signatures that are characteristic of subtypes of gastric cancer and associated premalignant changes should enable further analysis of the steps involved in the initiation and progression of this disease.
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