牛痘
免疫原性
改良安卡拉痘苗
天花疫苗
医学
病毒学
接种疫苗
不利影响
免疫
免疫系统
免疫学
天花
抗体
生物
内科学
基因
生物化学
重组DNA
作者
Sharon E. Frey,Frances K. Newman,Jeffrey S. Kennedy,Francis A. Ennis,Getahun Abate,Daniel F. Hoft,Thomas P. Monath
出处
期刊:Vaccine
[Elsevier]
日期:2009-03-01
卷期号:27 (10): 1637-1644
被引量:77
标识
DOI:10.1016/j.vaccine.2008.11.079
摘要
Currently, more than half of the world's population has no immunity against smallpox variola major virus. This phase I double-blind, randomized trial was conducted to compare the safety and immunogenicity of two clonally derived, cell-culture manufactured vaccinia strains, ACAM1000 and ACAM2000, to the parent vaccine, Dryvax. Thirty vaccinia-naïve subjects were enrolled into each of three groups and vaccines were administered percutaneously using a bifurcated needle at a dose of 1.0x10(8)PFU/mL. All subjects had a primary skin reaction indicating a successful vaccination. The adverse events, 4-fold neutralizing antibody rise and T cell immune responses were similar between the groups.
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