生发中心
CD154
B细胞
淋巴结
淋巴
生物
免疫系统
免疫学
CD40
抗原
T细胞
淋巴细胞
细胞
细胞生物学
抗体
细胞毒性T细胞
医学
病理
遗传学
体外
作者
Paul Garside,Elizabeth Ingulli,Rebecca Merica,Julia G. Johnson,Randolph J. Noelle,Marc K. Jenkins
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1998-07-03
卷期号:281 (5373): 96-99
被引量:758
标识
DOI:10.1126/science.281.5373.96
摘要
Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell–rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.
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