Cisapride was effective in the short term for constipation in children

(2000) J Pediatr 136, 35. Nurko S, Garcia-Aranda JA, Worona LB, et al. . Cisapride for the treatment of constipation in children: a double-blind study. . Jan; . : . –40 . [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In children with constipation, what is the effectiveness of cisapride (a prokinetic agent)? 12 week randomised (allocation concealed*), blinded {clinicians, patients, outcome assessors, and statisticians}†* placebo controlled trial. Gastroenterology clinic of a hospital in Mexico City, Mexico. 40 children who were 2–16 years of age, had a history of chronic constipation, and had <3 bowel movements per week during a 2 week observation period before enrolment. Exclusion criteria were Hirschsprung disease, other congenital abnormalities of the gastrointestinal tract, or pelvic floor dyssynergia. Data were available for 36 patients (90%) (mean age 6 y, 67% boys). Patients were disimpacted and allocated to cisapride (n=17) or placebo (n=19) for 12 weeks. The medications were given as an oral suspension, 0.2 mg/kg of body weight per … [1]: {openurl}?query=rft.jtitle%253DThe%2BJournal%2Bof%2Bpediatrics%26rft.stitle%253DJ%2BPediatr%26rft.aulast%253DNurko%26rft.auinit1%253DS.%26rft.volume%253D136%26rft.issue%253D1%26rft.spage%253D35%26rft.epage%253D40%26rft.atitle%253DCisapride%2Bfor%2Bthe%2Btreatment%2Bof%2Bconstipation%2Bin%2Bchildren%253A%2BA%2Bdouble-blind%2Bstudy.%26rft_id%253Dinfo%253Adoi%252F10.1016%252FS0022-3476%252800%252990046-5%26rft_id%253Dinfo%253Apmid%252F10636971%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1016/S0022-3476(00)90046-5&link_type=DOI [3]: /lookup/external-ref?access_num=10636971&link_type=MED&atom=%2Febmed%2F5%2F5%2F150.atom [4]: /lookup/external-ref?access_num=000084910000011&link_type=ISI