Different Bifidobacterium bifidum strains change the intestinal flora composition of mice via different mechanisms to alleviate loperamide-induced constipation

B. bifidum had intraspecies differences in relieving constipation. It can promote intestinal peristalsis by gastrointestinal active peptides. Specially, FXJCJ32M2 may promote the expression of AQP8 and VIPR1 through gut microbiota modulation.