神经发生
聚唾液酸
室下区
亚颗粒带
齿状回
神经细胞粘附分子
神经科学
海马体
生物
海马结构
神经干细胞
细胞生物学
细胞
细胞粘附
干细胞
遗传学
作者
Eduardo Gascon,László Vutskits,Jozsef Z. Kiss
标识
DOI:10.1007/978-1-4419-1170-4_8
摘要
Recruitment of new neurons to existing circuits is a fascinating form of adult plasticity. In the mammalian brain, this process occurs in two discrete regions, the subventricular zone of the lateral ventricule (SVZ) and the subgranular zone of dentate gyrus (SGZ) in the hippocampus. Several recent studies suggest that isoforms of the neuronal cell adhesion molecule (NCAM) carrying the linear homopolymer of alpha 2,8-linked sialic acid (polysialic acid, PSA), play a role in regulating several steps of adult neurogenesis including migration, survival and process outgrowth of newly generated neurons. Here, we will review recent evidence on how PSA-NCAM might regulate the biological properties of new neurons in sites of adult neurogenesis.
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