谢弗侧枝
突触可塑性
长时程增强
神经科学
钙调神经磷酸酶
海马体
非突触性可塑性
生物
化学
变质塑性
医学
抑制性突触后电位
内科学
兴奋性突触后电位
生物化学
受体
移植
作者
Pei Xia,Zheng Yu,Lei Dong,Chunxiao Tian
标识
DOI:10.1021/acschemneuro.1c00500
摘要
In this study, we investigate the intrinsic mechanism by which an extremely low-frequency electromagnetic field (ELF-EMF) influences neurons in the Schaffer collateral-CA1 (SC-CA1) region of rat hippocampus using electrophysiological techniques. ELF-EMF has an interesting effect on synaptic plasticity: it weakens long-term potentiation and enhances long-term depression. Here, the magnetic field effect disappeared after a blockade of voltage-gated calcium channels and calcineurin, which are key components in the Ca2+/calcineurin pathway, with two blockers, cadmium chloride and cyclosporin A. This fully establishes that the effect of ELF-EMF on synaptic plasticity is mediated by the Ca2+/calcineurin pathway and represents a novel technique for studying the specific mechanisms of action of ELF-EMF on learning and memory.
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