Patterns of immune infiltration in gastric cancer and their clinical significance

医学 肿瘤浸润淋巴细胞 癌症 肿瘤微环境 渗透(HVAC) 免疫系统 癌细胞 癌症研究 内科学 临床意义 免疫学 病理 肿瘤科 转移 免疫疗法 物理 热力学
作者
Yin-Fu Jin,Liping Tao,Shuqing Jin,Weiyang Cai
出处
期刊:Japanese Journal of Clinical Oncology [Oxford University Press]
卷期号:51 (7): 1067-1079 被引量:1
标识
DOI:10.1093/jjco/hyab054
摘要

Abstract Objective The malignant phenotypes of cancer are defined not only by its intrinsic tumor cells but also by the tumor-infiltrating immune cells activated and recruited to the cancer microenvironment. However, a comprehensive introduction of gastric cancer immune cell infiltration has not been identified so far. Methods In this study, we comprehensively analyzed the tumor-infiltrating immune cells abundance in gastric cancer for the first time by CIBERSORT. The meta-analysis, single-sample gene set enrichment analysis and hierarchical agglomerative clustering were used to measure and evaluate the respective proportions of 22 cell types of immune infiltration using normalized gene expression data. The fraction of tumor-infiltrating immune cells subpopulations was also evaluated to determine the associations with clinical features and molecular subtypes. Results Tumor-infiltrating immune cells are extensively involved in the pathogenesis and development of the gastric cancer. We discovered Tfh and activated CD4+ memory T cells were associated with poorer overall survival and Progression-free survival (PFS), but that naïve B cells were opposite for PFS. Unsupervised clustering analysis revealed there existed three tumor-infiltrating immune cells subgroups with distinct survival patterns. Specially, cluster 1 showed significantly better clinical outcome than other two clusters. Conclusions Collectively, our data explored the differences of tumor-infiltrating immune cells in gastric cancer, and these variations were likely to be important clues for prognosis and management of its future clinical implementation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
carbon-dots发布了新的文献求助10
刚刚
脑洞疼应助lin采纳,获得10
2秒前
Murphy_H完成签到,获得积分10
2秒前
2秒前
张晓完成签到 ,获得积分10
2秒前
橘子汽水完成签到 ,获得积分10
2秒前
lsybf发布了新的文献求助20
3秒前
yu完成签到,获得积分10
3秒前
3秒前
我是老大应助bhappy21采纳,获得10
4秒前
东瓜山完成签到 ,获得积分10
4秒前
Creamai发布了新的文献求助10
5秒前
爱吃泡芙完成签到,获得积分10
5秒前
carbon-dots完成签到,获得积分10
5秒前
朱之欣完成签到,获得积分10
5秒前
科学家完成签到,获得积分10
6秒前
6秒前
gyr发布了新的文献求助10
7秒前
jlkb完成签到,获得积分10
8秒前
control完成签到,获得积分10
8秒前
竹子完成签到,获得积分10
8秒前
feitian201861完成签到,获得积分10
9秒前
9秒前
LZY完成签到,获得积分10
10秒前
小桑桑完成签到,获得积分10
10秒前
Olives完成签到,获得积分10
10秒前
moon完成签到,获得积分10
11秒前
乌龟娟完成签到,获得积分10
11秒前
柳絮旭完成签到 ,获得积分10
12秒前
与其感慨前路难行关注了科研通微信公众号
12秒前
严剑封完成签到,获得积分10
12秒前
在水一方应助LZY采纳,获得10
13秒前
13秒前
yhb发布了新的文献求助10
13秒前
lonelymusic完成签到,获得积分10
14秒前
大海是故乡完成签到,获得积分10
14秒前
求求接收吧完成签到,获得积分10
15秒前
包容友儿完成签到,获得积分10
15秒前
简单的凝蕊完成签到,获得积分10
15秒前
huhu发布了新的文献求助10
15秒前
高分求助中
Evolution 10000
Becoming: An Introduction to Jung's Concept of Individuation 600
Distribution Dependent Stochastic Differential Equations 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
The Kinetic Nitration and Basicity of 1,2,4-Triazol-5-ones 440
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3158960
求助须知:如何正确求助?哪些是违规求助? 2810082
关于积分的说明 7886047
捐赠科研通 2468944
什么是DOI,文献DOI怎么找? 1314470
科研通“疑难数据库(出版商)”最低求助积分说明 630632
版权声明 602012