Patterns of immune infiltration in gastric cancer and their clinical significance

医学 肿瘤浸润淋巴细胞 癌症 肿瘤微环境 渗透(HVAC) 免疫系统 癌细胞 癌症研究 内科学 临床意义 免疫学 病理 肿瘤科 转移 免疫疗法 物理 热力学
作者
Yin-Fu Jin,Liping Tao,Shuqing Jin,Weiyang Cai
出处
期刊:Japanese Journal of Clinical Oncology [Oxford University Press]
卷期号:51 (7): 1067-1079 被引量:1
标识
DOI:10.1093/jjco/hyab054
摘要

Abstract Objective The malignant phenotypes of cancer are defined not only by its intrinsic tumor cells but also by the tumor-infiltrating immune cells activated and recruited to the cancer microenvironment. However, a comprehensive introduction of gastric cancer immune cell infiltration has not been identified so far. Methods In this study, we comprehensively analyzed the tumor-infiltrating immune cells abundance in gastric cancer for the first time by CIBERSORT. The meta-analysis, single-sample gene set enrichment analysis and hierarchical agglomerative clustering were used to measure and evaluate the respective proportions of 22 cell types of immune infiltration using normalized gene expression data. The fraction of tumor-infiltrating immune cells subpopulations was also evaluated to determine the associations with clinical features and molecular subtypes. Results Tumor-infiltrating immune cells are extensively involved in the pathogenesis and development of the gastric cancer. We discovered Tfh and activated CD4+ memory T cells were associated with poorer overall survival and Progression-free survival (PFS), but that naïve B cells were opposite for PFS. Unsupervised clustering analysis revealed there existed three tumor-infiltrating immune cells subgroups with distinct survival patterns. Specially, cluster 1 showed significantly better clinical outcome than other two clusters. Conclusions Collectively, our data explored the differences of tumor-infiltrating immune cells in gastric cancer, and these variations were likely to be important clues for prognosis and management of its future clinical implementation.
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