间苯二甲酸
麻醉
化学
晶体结构
聚合物
配体(生物化学)
医学
配位聚合物
对接(动物)
立体化学
镧系元素
药理学
受体
结晶学
有机化学
生物化学
聚酯纤维
离子
护理部
对苯二甲酸
作者
Jinghong Xu,Zhuo‐Wei Wang,Xia Xu,Wei Peng
标识
DOI:10.1080/24701556.2021.1956957
摘要
In the present research, a new coordination polymer with the chemical formula of [PrCl(HL)]n (1) was synthesized by utilizing the pure chiral tricarboxyl ligand (S)-5-(((1-carboxy-2-phenylethyl)amino)methyl)isophthalic acid (H3L). The important role of the new compound on prevention of hypotension after anesthesia and the bio-toxicity was evaluated, and at the same time, the relevant mechanism was also be investigated. The conclusive outcome of the present work from the molecular docking simulation identification is that the carboxyl and imino groups are interacting with the active sites on the alpha-2A-adrenergic receptor, which reveals the underlaying reason of the biological activity of the complex.
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