细胞生物学
钙粘蛋白
普氏球蛋白
细胞结
桥粒蛋白
形态发生
细胞粘附
桥粒
桥粒蛋白
生物
细胞
连环素
信号转导
Wnt信号通路
遗传学
基因
作者
Marihan Hegazy,Abbey Perl,Sophia Svoboda,Kathleen J. Green
出处
期刊:Annual Review of Pathology-mechanisms of Disease
[Annual Reviews]
日期:2022-01-24
卷期号:17 (1): 47-72
被引量:55
标识
DOI:10.1146/annurev-pathol-042320-092912
摘要
Desmosomal cadherins are a recent evolutionary innovation that make up the adhesive core of highly specialized intercellular junctions called desmosomes. Desmosomal cadherins, which are grouped into desmogleins and desmocollins, are related to the classical cadherins, but their cytoplasmic domains are tailored for anchoring intermediate filaments instead of actin to sites of cell-cell adhesion. The resulting junctions are critical for resisting mechanical stress in tissues such as the skin and heart. Desmosomal cadherins also act as signaling hubs that promote differentiation and facilitate morphogenesis, creating more complex and effective tissue barriers in vertebrate tissues. Interference with desmosomal cadherin adhesive and supra-adhesive functions leads to a variety of autoimmune, hereditary, toxin-mediated, and malignant diseases. We review our current understanding of how desmosomal cadherins contribute to human health and disease, highlight gaps in our knowledge about their regulation and function, and introduce promising new directions toward combatting desmosome-related diseases.
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