嵌合抗原受体
癌症免疫疗法
免疫疗法
医学
细胞疗法
癌症
范围(计算机科学)
免疫系统
免疫学
癌症研究
计算机科学
生物
细胞
内科学
遗传学
程序设计语言
作者
Alejandrina Hernández-López,Mario A. Téllez-González,Paul Mondragón‐Terán,Angélica Meneses‐Acosta
标识
DOI:10.3389/fphar.2021.720692
摘要
Cancer is among the leading causes of death worldwide. Therefore, improving cancer therapeutic strategies using novel alternatives is a top priority on the contemporary scientific agenda. An example of such strategies is immunotherapy, which is based on teaching the immune system to recognize, attack, and kill malignant cancer cells. Several types of immunotherapies are currently used to treat cancer, including adoptive cell therapy (ACT). Chimeric Antigen Receptors therapy (CAR therapy) is a kind of ATC where autologous T cells are genetically engineered to express CARs (CAR-T cells) to specifically kill the tumor cells. CAR-T cell therapy is an opportunity to treat patients that have not responded to other first-line cancer treatments. Nowadays, this type of therapy still has many challenges to overcome to be considered as a first-line clinical treatment. This emerging technology is still classified as an advanced therapy from the pharmaceutical point of view, hence, for it to be applied it must firstly meet certain requirements demanded by the authority. For this reason, the aim of this review is to present a global vision of different immunotherapies and focus on CAR-T cell technology analyzing its elements, its history, and its challenges. Furthermore, analyzing the opportunity areas for CAR-T technology to become an affordable treatment modality taking the basic, clinical, and practical aspects into consideration.
科研通智能强力驱动
Strongly Powered by AbleSci AI