Tumor Therapy: In Situ Tumor Vaccination with Nanoparticle Co‐Delivering CpG and STAT3 siRNA to Effectively Induce Whole‐Body Antitumor Immune Response (Adv. Mater. 31/2021)

In article number 2100628, Wassana Yantasee and co-workers investigate how Augmenting Immune Response and Inhibiting Suppressive Environment of tumors-02 (AIRISE-02) activates an antitumor immune response. AIRISE-02 is a nanoparticle co-delivering STAT3 siRNA and CpG intratumorally, utilizing local tumor antigens to train the immune system to kill cancer throughout the body. AIRISE-02 shows strong efficacy in various tumor models, and favorable safety in mice and monkeys.