心房颤动
心脏病学
医学
内科学
斑点追踪超声心动图
前瞻性队列研究
接收机工作特性
逻辑回归
曲线下面积
射血分数
心力衰竭
作者
Takashi Hirose,Masanori Kawasaki,Ryuji Tanaka,Koji Ono,Tetsu Watanabe,Makoto Itō,Toshiyuki Noda,Shozo Watanabe,Genzou Takemura,Shingo Minatoguchi
出处
期刊:European Journal of Echocardiography
[Oxford University Press]
日期:2011-11-25
卷期号:13 (3): 243-250
被引量:125
标识
DOI:10.1093/ejechocard/jer251
摘要
The aim of this prospective study was to evaluate left atrial (LA) function for the prediction of increased risk of new-onset non-valvular atrial fibrillation (AF). Risk stratification for new-onset AF based on LA remodelling may have a major public health impact. Although left atrial volume (LAV) or LA dimension have been proposed as predictors of AF, other predictive parameters of LA function have not yet been fully examined. LA emptying function (EF), strain rate (SR), and LAV were evaluated in the apical four-chamber view by speckle tracking echocardiography in 580 consecutive adults (age 64 ± 17, 303 men) without a history of atrial arrhythmias. During a follow-up period of 28 months, 32 subjects (age 73 ± 9, 18 men) developed electrocardiographically confirmed AF. Subjects with new-onset AF had lower LA active EF (16 ± 5 vs. 28 ± 8%, P< 0.001) and lower LA SR at atrial contraction (−0.9 ± 0.2 vs. −1.4 ± 0.5 S−1, P< 0.001), but larger maximum LAV index (59 ± 12 vs. 46 ± 16 mL/m2, P< 0.001) compared with non-AF subjects at baseline. In multivariate logistic regression analysis, LA active EF was the only independent predictor of new-onset AF. Using an LA active EF cut-off of ≤20%, the sensitivity and specificity for new-onset AF based on receiver operator characteristic curve analysis were 88 and 81%, respectively (area under the curve: 0.92). Reduced LA active EF (booster pump function) assessed by speckle tracking echocardiography independently predicts the risk of new-onset AF, suggesting a stronger association between LA functional remodelling and AF than between LA size and AF.
科研通智能强力驱动
Strongly Powered by AbleSci AI