自噬
自噬体
细胞生物学
生物
内质网
液泡
细胞质
细胞器
吞噬体
小泡
细胞内
生物化学
膜
细胞凋亡
作者
David M. Hollenstein,Claudine Kraft
标识
DOI:10.1016/j.ceb.2020.02.012
摘要
Autophagy is characterized by the formation of double-membrane vesicles called autophagosomes, which deliver bulk cytoplasmic material to the lytic compartment of the cell for degradation. Autophagosome formation is initiated by assembly and recruitment of the core autophagy machinery to distinct cellular sites, referred to as phagophore assembly sites (PAS) in yeast or autophagosome formation sites in other organisms. A large number of autophagy proteins involved in the formation of autophagosomes has been identified; however, how the individual components of the PAS are assembled and how they function to generate autophagosomes remains a fundamental question. Here, we highlight recent studies that provide molecular insights into PAS organization and the role of the endoplasmic reticulum and the vacuole in autophagosome formation.
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