生物
肝细胞癌
转录组
癌症研究
癌症
表型
基因
六氯环己烷
基因表达
遗传学
作者
Pedro Molina-Sánchez,Marina Ruiz de Galarreta,Melissa A. Yao,Katherine E. Lindblad,Erin Bresnahan,Elizabeth Bitterman,Tiphaine Martin,Troy Rubenstein,Kai Nie,Jonathon Golas,Shambhunath Choudhary,Marina Bárcena‐Varela,Abdulkadir Elmas,Verónica Miguela,Ying Ding,Zhengyan Kan,Lauren Tal Grinspan,Kuan‐lin Huang,Ramon Parsons,David J. Shields,Robert A. Rollins,Amaia Lujambio
出处
期刊:Gastroenterology
[Elsevier]
日期:2020-12-01
卷期号:159 (6): 2203-2220.e14
被引量:54
标识
DOI:10.1053/j.gastro.2020.08.015
摘要
The pattern of genetic alterations in cancer driver genes in patients with hepatocellular carcinoma (HCC) is highly diverse, which partially explains the low efficacy of available therapies. In spite of this, the existing mouse models only recapitulate a small portion of HCC inter-tumor heterogeneity, limiting the understanding of the disease and the nomination of personalized therapies. Here, we aimed at establishing a novel collection of HCC mouse models that captured human HCC diversity.
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