已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Role of serum HBV RNA and hepatitis B surface antigen levels in identifying Asian patients with chronic hepatitis B suitable for entecavir cessation

恩替卡韦 乙型肝炎表面抗原 医学 胃肠病学 内科学 乙型肝炎病毒 乙型肝炎 慢性肝炎 免疫学 病毒 拉米夫定
作者
Wai‐Kay Seto,K. S. H. Liu,Lung‐Yi Mak,Gavin Cloherty,Danny Ka‐Ho Wong,Jeffrey Gersch,Yuk-Fai Lam,Ka Shing Cheung,Ning Chow,Kwan‐Lung Ko,Wai‐Pan To,James Fung,Man‐Fung Yuen
出处
期刊:Gut [BMJ]
卷期号:70 (4): 775-783 被引量:80
标识
DOI:10.1136/gutjnl-2020-321116
摘要

Background Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. Methods Nucleos(t)ide analogue (NUC) treatment was discontinued in non-cirrhotic patients with chronic HBV with serum HBsAg <200 IU/mL and fulfilling internationally recommended criteria for treatment cessation. Patients were monitored till 48 weeks with baseline and serial measurements of serum HBsAg, HBV RNA and hepatitis B core-related antigen. NUCs were resumed when HBV DNA reaches >2000 IU/mL regardless of alanine aminotransferase (ALT) levels. Results 114 entecavir-treated patients (median age 58.4 years, median serum HBsAg 54.4 IU/mL) with median treatment duration of 6.7 years were recruited. The 48-week cumulative rate of HBV DNA >2000 IU/mL was 58.1%. End-of-treatment serum HBV RNA and off-treatment serial HBV RNA were both independently associated with HBV DNA >2000 IU/mL (HR 2.959, 95% CI 1.776 to 4.926, p<0.001; HR 2.278, 95% CI 1.151 to 4.525, p=0.018, respectively). Patients with HBV RNA ≥44.6 U/mL had a cumulative 48-week rate of 93.2%, while combining HBV RNA undetectability and HBsAg <10 IU/mL had a cumulative 48-week rate of 9.1%. 24 patients (38.7%) developed off-treatment ALT elevation, highest peak ALT was 1515 U/L. 8 patients (median serum HBsAg 2.6 IU/mL) developed HBsAg seroclearance. Conclusion Serum HBV RNA measurement is essential for deciding on entecavir cessation in patients with chronic HBV, especially with low HBsAg levels. Patients can be stratified on their risk of off-treatment relapse based on both viral determinants. Trial registration number NCT02738554
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
白斯特发布了新的文献求助10
1秒前
藏沙完成签到 ,获得积分10
2秒前
7秒前
10秒前
米米发布了新的文献求助10
12秒前
晚意意意意意完成签到 ,获得积分10
13秒前
20秒前
21秒前
22秒前
shinysparrow应助Hung采纳,获得200
23秒前
虚幻初之发布了新的文献求助10
23秒前
清逸完成签到 ,获得积分10
26秒前
張医铄完成签到,获得积分10
26秒前
Orange应助Vivian采纳,获得10
27秒前
turbohero发布了新的文献求助10
29秒前
潇洒绿蕊完成签到,获得积分10
31秒前
lulu完成签到 ,获得积分10
32秒前
maolao发布了新的文献求助10
33秒前
归海梦岚完成签到,获得积分0
34秒前
CodeCraft应助zzholiver采纳,获得10
34秒前
维尼完成签到,获得积分10
36秒前
清爽的傲易完成签到 ,获得积分10
40秒前
dong应助于某人采纳,获得10
42秒前
42秒前
菠萝完成签到 ,获得积分10
43秒前
muderder完成签到 ,获得积分20
44秒前
gggggg完成签到 ,获得积分10
46秒前
zzholiver发布了新的文献求助10
47秒前
47秒前
不爱吃西葫芦完成签到 ,获得积分10
50秒前
dy完成签到 ,获得积分10
52秒前
量子星尘发布了新的文献求助10
52秒前
缥缈的芷卉完成签到 ,获得积分10
55秒前
Yan完成签到,获得积分10
57秒前
Janice完成签到 ,获得积分10
58秒前
多肉葡萄完成签到 ,获得积分10
59秒前
有魅力的安蕾完成签到 ,获得积分10
1分钟前
maolao完成签到,获得积分10
1分钟前
旺仔小馒头完成签到 ,获得积分10
1分钟前
LUJyyyy完成签到,获得积分10
1分钟前
高分求助中
The Mother of All Tableaux Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 2400
Ophthalmic Equipment Market by Devices(surgical: vitreorentinal,IOLs,OVDs,contact lens,RGP lens,backflush,diagnostic&monitoring:OCT,actorefractor,keratometer,tonometer,ophthalmoscpe,OVD), End User,Buying Criteria-Global Forecast to2029 2000
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Cognitive Neuroscience: The Biology of the Mind (Sixth Edition) 1000
Optimal Transport: A Comprehensive Introduction to Modeling, Analysis, Simulation, Applications 800
Official Methods of Analysis of AOAC INTERNATIONAL 600
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3959928
求助须知:如何正确求助?哪些是违规求助? 3506172
关于积分的说明 11128138
捐赠科研通 3238123
什么是DOI,文献DOI怎么找? 1789535
邀请新用户注册赠送积分活动 871803
科研通“疑难数据库(出版商)”最低求助积分说明 803024