血管炎
直接荧光抗体
免疫荧光
医学
结缔组织
皮肤病科
活检
结缔组织病
病理
抗体
疾病
免疫学
自身免疫性疾病
作者
Randie H. Kim,Nooshin K. Brinster
出处
期刊:American Journal of Dermatopathology
[Ovid Technologies (Wolters Kluwer)]
日期:2020-01-28
卷期号:42 (2): 75-85
被引量:21
标识
DOI:10.1097/dad.0000000000001516
摘要
Direct immunofluorescence (DIF) remains a valuable tool that may be underused because of perceived challenges in the interpretation, limitations, and processing of DIF specimens. The aim of this review is to provide a practical guide for appropriately incorporating DIF in a variety of clinical diseases, such as autoimmune blistering disorders. In vasculitis, the role of DIF continues to evolve, particularly in the setting of IgA vasculitis. Although typically not indicated for the workup of connective tissue disease, DIF may be helpful in cases with negative serologies, nondiagnostic histologic findings, or scarring alopecia. Practical pearls for biopsy technique, specimen handling, and storage are also discussed.
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