Synergistic protection of astragalus polysaccharides and matrine against ulcerative colitis and associated lung injury in rats

苦参碱 丙二醛 封堵器 髓过氧化物酶 炎症性肠病 超氧化物歧化酶 溃疡性结肠炎 医学 氧化应激 药理学 结肠炎 免疫学 病理 内科学 化学 炎症 生物化学 紧密连接 精神科 疾病
作者
Xin Yan,Qingge Lu,Li Zeng,Xiao-Hai Li,Yu Liu,Xianjin Du,Ge Bai
出处
期刊:World Journal of Gastroenterology [Baishideng Publishing Group Co]
卷期号:26 (1): 55-69 被引量:23
标识
DOI:10.3748/wjg.v26.i1.55
摘要

Ulcerative colitis (UC) is a main form of inflammatory bowel disease. Due to complicated etiology and a high rate of recurrence, it is quite essential to elucidate the underlying mechanism of and search for effective therapeutic methods for UC.To investigate the effects of astragalus polysaccharides (APS) combined with matrine on UC and associated lung injury.UC was induced in rats by colon mucosal tissue sensitization combined with trinitro-benzene-sulfonic acid-ethanol. Then, the effects of the treatments of salazopyrine, APS, matrine, and APS combined with matrine on histopathological changes of lung and colon tissues, disease activity index (DAI), colon mucosal damage index (CMDI), serum endotoxin (ET) level, serum diamine oxidase (DAO) activity, the contents of tumor necrosis factor-α and interleukin-1β, and the activities of myeloperoxidase, superoxide dismutase, and malondialdehyde in lung tissues, as well as the protein expression of zonula occludens (ZO)-1, Occludin, and trefoil factor 3 (TFF3) were detected in UC rats.The treatments of salazopyrine, APS, matrine, and APS combined with matrine reduced DAI scores and improved histopathological changes of colon and lung tissues, as well as decreased CMDI scores, ET levels, and DAO activities in UC rats. Moreover, in lung tissues, inflammatory response and oxidative stress injury were relieved after the treatments of salazopyrine, APS, matrine, and APS combined with matrine in UC rats. Furthermore, the expression of ZO-1, Occludin, and TFF3 in lung and colon tissues was increased after different treatments in UC rats. Notably, APS combined with matrine exerted a better protective effect against UC and lung injury compared with other treatments.APS combined with matrine exert a synergistic protective effect against UC and lung injury, which might be associated with regulating TFF3 expression.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
嘴角上扬完成签到 ,获得积分10
1秒前
桐安发布了新的文献求助10
1秒前
huanir99发布了新的文献求助10
2秒前
柏代桃发布了新的文献求助10
2秒前
江河JT完成签到 ,获得积分10
2秒前
顺心孤云发布了新的文献求助10
2秒前
3秒前
3秒前
interest-li完成签到,获得积分10
5秒前
6秒前
6秒前
研友_8DAv0L发布了新的文献求助10
6秒前
zhouzhou发布了新的文献求助10
6秒前
hhh发布了新的文献求助20
6秒前
qian完成签到,获得积分10
6秒前
荼柒完成签到,获得积分10
7秒前
虚幻的冷松完成签到,获得积分10
7秒前
八点必起发布了新的文献求助10
7秒前
科研小白发布了新的文献求助10
7秒前
10秒前
思源应助魅雪霓采纳,获得10
10秒前
TURBO发布了新的文献求助10
11秒前
12秒前
Yi发布了新的文献求助30
13秒前
13秒前
领导范儿应助zhangling采纳,获得10
13秒前
14秒前
14秒前
14秒前
大模型应助shai_ga采纳,获得10
15秒前
Misaki发布了新的文献求助10
15秒前
冰糖葫卢完成签到,获得积分10
16秒前
荼柒完成签到,获得积分10
17秒前
17秒前
lunar发布了新的文献求助10
17秒前
18秒前
老王发布了新的文献求助10
18秒前
忘忧草发布了新的文献求助10
18秒前
JamesPei应助研友_8DAv0L采纳,获得10
18秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3160777
求助须知:如何正确求助?哪些是违规求助? 2811863
关于积分的说明 7893780
捐赠科研通 2470702
什么是DOI,文献DOI怎么找? 1315762
科研通“疑难数据库(出版商)”最低求助积分说明 631003
版权声明 602053