Additional value of metabolic parameters to PET/CT-based radiomics nomogram in predicting lymphovascular invasion and outcome in lung adenocarcinoma

列线图 淋巴血管侵犯 医学 无线电技术 标准摄取值 内科学 放射科 正电子发射断层摄影术 核医学 癌症 转移
作者
Pei Nie,Guangli Yang,Ning Wang,Lei Yan,Wenjie Miao,Yanli Duan,Yanli Wang,Aidi Gong,Yongliang Zhao,Jie Wu,Chuantao Zhang,Maolong Wang,Jingjing Cui,Mingming Yu,Dacheng Li,Yanqin Sun,Yangyang Wang,Zhenguang Wang
出处
期刊:European Journal of Nuclear Medicine and Molecular Imaging [Springer Science+Business Media]
卷期号:48 (1): 217-230 被引量:45
标识
DOI:10.1007/s00259-020-04747-5
摘要

Lymphovascular invasion (LVI) impairs surgical outcomes in lung adenocarcinoma (LAC) patients. Preoperative prediction of LVI is challenging by using traditional clinical and imaging parameters. The purpose of this study was to investigate the value of the radiomics nomogram integrating clinical factors, CT features, and maximum standardized uptake value (SUVmax) to predict LVI and outcome in LAC and to evaluate the additional value of the SUVmax to the PET/CT-based radiomics nomogram. A total of 272 LAC patients (87 LVI-present LACs and 185 LVI-absent LACs) with PET/CT scans were retrospectively enrolled, and 160 patients with SUVmax ≥ 2.5 of them were used for PET radiomics analysis. Clinical data and CT features were analyzed to select independent LVI predictors. The performance of the independent LVI predictors and SUVmax was evaluated. Two-dimensional (2D) and three-dimensional (3D) CT radiomics signatures (RSs) and PET-RS were constructed with the least absolute shrinkage and selection operator algorithm and radiomics scores (Rad-scores) were calculated. The radiomics nomograms, incorporating Rad-score and independent clinical and CT factors, with SUVmax (RNWS) or without SUVmax (RNWOS) were built. The performance of the models was assessed with respect to calibration, discrimination, and clinical usefulness. All the clinical, PET/CT, pathologic, therapeutic, and radiomics parameters were assessed to identify independent predictors of progression-free survival (PFS). CT morphology was the independent LVI predictor. SUVmax provided better discrimination capability compared with CT morphology in the training set (P   0.05), and 2D CT-RS showed a relatively higher AUC than 3D CT-RS. The CT-RS, the CT-RNWOS, and the CT-RNWS showed good discrimination in the training set (AUC [area under the curve], 0.799, 0.796, and 0.851, respectively) and the test set (AUC, 0.818, 0.822, and 0.838, respectively). There was significant difference in AUC between the CT-RNWS and CT-RNWOS (P = 0.044) in the training set. Decision curve analysis (DCA) demonstrated the CT-RNWS outperformed the CT-RS and the CT-RNWOS in terms of clinical usefulness. Furthermore, DCA showed the PETCT-RNWS provided the highest net benefit compared with the PET-RNWS and CT-RNWS. PFS was significantly different between the pathologic and RNWS-predicted LVI-present and LVI-absent patients (P < 0.001). Carbohydrate antigen 125 (CA125), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), pathologic LVI, histologic subtype, and SUVmax were independent predictors of PFS in the 244 CT-RNWS-predicted cohort; and CA125, NSE, pathologic LVI, and SUVmax were the independent predictors of PFS in the 141 PETCT-RNWS-predicted cohort. The radiomics nomogram, incorporating Rad-score, clinical and PET/CT parameters, shows favorable predictive efficacy for LVI status in LAC. Pathologic LVI and SUVmax are associated with LAC prognosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
NexusExplorer应助科研通管家采纳,获得10
刚刚
SciGPT应助科研通管家采纳,获得10
刚刚
科研通AI2S应助科研通管家采纳,获得10
刚刚
今后应助科研通管家采纳,获得10
1秒前
所所应助科研通管家采纳,获得10
1秒前
在水一方应助科研通管家采纳,获得10
1秒前
CAOHOU应助科研通管家采纳,获得10
1秒前
CAOHOU应助科研通管家采纳,获得10
1秒前
小马甲应助科研通管家采纳,获得20
1秒前
1秒前
1秒前
梅卡完成签到 ,获得积分10
2秒前
111发布了新的文献求助10
2秒前
酷波er应助飞快的夜天采纳,获得10
4秒前
4秒前
4秒前
范月月完成签到 ,获得积分10
5秒前
sirhai发布了新的文献求助10
6秒前
6秒前
NexusExplorer应助少敏敏采纳,获得10
6秒前
英姑应助罗拉采纳,获得10
8秒前
小爪冰凉发布了新的文献求助10
8秒前
8秒前
8秒前
苏孖发布了新的文献求助20
8秒前
Qi完成签到 ,获得积分10
9秒前
百事可乐完成签到 ,获得积分10
11秒前
李嘉欣发布了新的文献求助10
11秒前
小万完成签到,获得积分10
12秒前
Lucas应助开灯人和关灯人采纳,获得10
12秒前
怕孤独的冰淇淋完成签到,获得积分10
13秒前
禹与于发布了新的文献求助10
14秒前
persist发布了新的文献求助10
14秒前
向上发布了新的文献求助10
15秒前
量子星尘发布了新的文献求助10
15秒前
111完成签到,获得积分10
15秒前
16秒前
Heartlark完成签到,获得积分10
18秒前
20秒前
罗拉发布了新的文献求助10
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173