Research advances in the study of the regulatory effect of mTOR inhibitor-rapamycin on dendritic cells

The mammalian target of rapamycin (mTOR) in innate and adaptive immune responses is becoming apparent. mTOR regulates diverse functions of dendritic cells (DCs), such as DC differentiation,maturation, survival, migration, antigen uptake and presentation, and cytokine production. The immunosuppressive effect of rapamycin is achieved by inhibiting mTOR and impairing the maturation and functions of DC. Key words: Mammalian target of rapamycin;  Rapamycin;  Dendritic cell;  Functional regulation