坏死性下垂
失巢
自噬
程序性细胞死亡
内质网
黑色素瘤
细胞生物学
癌症研究
细胞凋亡
未折叠蛋白反应
细胞
生物
遗传学
作者
Milad Ashrafizadeh,Reza Mohammadinejad,Shima Tavakol,Zahra Ahmadi,Sahar Saeedi Moghaddam,Majid Katebi
摘要
Melanoma as the most major skin malignancy has attracted much attention, so far. Although a successful therapeutic strategy requires an accurate understanding of the precise mechanisms for the initiation and progression of the melanoma. Several types of cell death mechanisms have recently been identified along with conventional cell death mechanisms such as apoptosis and necrosis. Among those mechanisms, necroptosis, anoikis, ferroptosis, and autophagy may be considered to have remarkable modulatory impacts on melanoma. In the present review, we explain the mechanisms of cell death signaling pathways related to autophagy, ferroptosis, anoikis, necroptosis, and reticulum endoplasmic stress in cells and describe how those mechanisms transduce signals in melanoma cells. Meanwhile, we describe how we can modulate those mechanisms to eliminate melanoma.
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