抗菌剂
纳米技术
介孔二氧化硅
抗生素
表面改性
生物膜
材料科学
药物输送
抗生素耐药性
介孔材料
纳米材料
化学
微生物学
细菌
生物
催化作用
物理化学
生物化学
遗传学
作者
Andrea Bernardos,Elena Piacenza,Félix Sancenón,Mehrdad Hamidi,Aziz Maleki,Raymond J. Turner,Ramón Martínez‐Máñez
出处
期刊:Small
[Wiley]
日期:2019-04-29
卷期号:15 (24)
被引量:141
标识
DOI:10.1002/smll.201900669
摘要
Abstract Bacterial infections are the main cause of chronic infections and even mortality. In fact, due to extensive use of antibiotics and, then, emergence of antibiotic resistance, treatment of such infections by conventional antibiotics has become a major concern worldwide. One of the promising strategies to treat infection diseases is the use of nanomaterials. Among them, mesoporous silica materials (MSMs) have attracted burgeoning attention due to high surface area, tunable pore/particle size, and easy surface functionalization. This review discusses how one can exploit capacities of MSMs to design and fabricate multifunctional/controllable drug delivery systems (DDSs) to combat bacterial infections. At first, the emergency of bacterial and biofilm resistance toward conventional antimicrobials is described and then how nanoparticles exert their toxic effects upon pathogenic cells is discussed. Next, the main aspects of MSMs (e.g., physicochemical properties, multifunctionality, and biosafety) which one should consider in the design of MSM‐based DDSs against bacterial infections are introduced. Finally, a comprehensive analysis of all the papers published dealing with the use of MSMs for delivery of antibacterial chemicals (antimicrobial agents functionalized/adsorbed on mesoporous silica (MS), MS‐loaded with antimicrobial agents, gated MS‐loaded with antimicrobial agents, MS with metal‐based nanoparticles, and MS‐loaded with metal ions) is provided.
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