声动力疗法
医学
高强度聚焦超声
前列腺癌
癌症
超声波
不利影响
放射科
内科学
作者
Yuki Horise,Masanori Maeda,Yoshiyuki Konishi,Jun Okamoto,Soko Ikuta,Yoshiharu Okamoto,Hiroshi Ishii,Shin Yoshizawa,Shin‐ichiro Umemura,Takeshi Ueyama,Satoshi Tamano,Atsushi Sofuni,Kazuhisa Takemae,Ken Masamune,Hiroshi Iseki,Nobuhiro Nishiyama,Kazunori Kataoka,Yoshihiro Muragakı
标识
DOI:10.3389/fphar.2019.00545
摘要
Sonodynamic therapy (SDT) is a minimally invasive anticancer therapy involving a chemical sonosensitizer and high-intensity focused ultrasound (HIFU). SDT enables the reduction of drug dose and HIFU irradiation power compared to those of conventional monotherapies. In our previous study, mouse models of colon and pancreatic cancer were used to confirm the effectiveness of SDT vs. drug-only or HIFU-only therapy. To validate its usefulness, we performed a clinical trial of SDT using an anticancer micelle (NC-6300) and our HIFU system in four pet dogs with spontaneous tumors, including chondrosarcoma, osteosarcoma, hepatocellular cancer, and prostate cancer. The fact that no adverse events were observed, suggests the usefulness of SDT.
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