混凝级联
凝结
化学
凝血酶
作用机理
药理学
抗凝剂
计算生物学
医学
生物化学
生物
免疫学
体外
外科
血小板
内科学
作者
Nicolás Núñez-Navarro,Fabián Santana-Romo,Loreto P. Parra,Flavia C. Zacconi
标识
DOI:10.2174/0929867325666180125165340
摘要
Factor Xa (FXa) plays a key role in haemostasis, it is a central part of the blood coagulation cascade which catalyzes the production of thrombin and leads to clot formation and wound closure. Therefore, FXa is an attractive target for the development of new anticoagulant agents. In this review, we will first describe the molecular features of this fundamental protein in order to understand its mechanism of action, an essential background for the design of novel inhibitors by means of synthetic organic chemistry or using peptides obtained from recombinant methodologies. Then, we will review the current state of the synthesis of novel direct FXa inhibitors along with their mechanisms of action. Finally, approved reversal agents that aid in maintaining blood haemostasis by using these commercial drugs will also be discussed.
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