浆液性囊腺癌
浆液性卵巢癌
浆液性液体
囊腺癌
病理
免疫组织化学
卵巢癌
聚合酶链反应
鉴别诊断
生物
分子生物学
癌症研究
医学
基因
癌症
遗传学
作者
Ying Yang,Jian Hou,Luyun Qu,Guiqing Wang,JU Hong-wei,Zhiwei Zhao,Zhenhai Yu,Huijun Yang
出处
期刊:PubMed
日期:2007-06-01
卷期号:23 (6): 504-6
被引量:10
摘要
The differential expression of USP2, USP14 and UBE4A between ovarian serous cystadenocarcinoma and adjacent normal tissues was investigated.Restriction fragment differential display polymerase chain reaction (RFDD-PCR), semi-quantitative RT-PCR and immunohistochemical staining were applied to analyze the differentially expressed genes and proteins of ubiquitin specific proteases (USPs), USP2 and USP14, and ubiquitin factor E4A (UBE4A) between ovarian serous cystadenocarcinoma and adjacent normal tissues obtained from 40 patients aged from 29 to 72 years old, collected in 2005 year at excision of surgical operation with ovarian serous cystadenocarcinoma.USP2, USP14 and UBE4A were over-expressed (>3 folds) in ovarian serous cystadenocarcinoma tissues compared to normal tissues.The results suggest that the activity of ubiquitin-proteasome system is obviously enhanced in ovarian cancer.
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