腺苷脱氨酶（ADA）联合ALT,AST,GGT在肝脏疾病中的诊断价值

Objective To study the significances of detecting ADA combined ALT,AST, and GGT for patients with hepatic diseases in diagnosis , differential diagnosis and prognosis of hepatic diseases. Methods We detected serum ADA , AST,ALT and GGT of 132 patients with hepatic diseases. There were 40 cases in the control group. Results ADA for the cirrhosis group was 56.2± 29. 7 U/L and the positive rate was 92. 6%. For acute hepatitis group , they were 47.3± 14.6U/L and 82.6%respectively. For chronic active hepatitis group , they were 2 9 . 6 ± 2 6 . 3 U/L and68.4%respectively. They were al significantly higher than those of the control group. ALT was increasing for the acute hepatitis group and the cirrhosis group. which the positive rate was 8 6 . 9%, 5 3 . 6%. GGT was also increasing for the acute hepatitis group and the cirrhosis group, which the positive rate was 5 6 . 8%, 5 9 . 3%. They were al significantly higher than those of the control group(P<0.01). Conclusion:The ADA measuration has relatively high sensitivity on liver disease diagnoses., Special in the acute hepatitis and liver cirrhosis are more obvious, ADA can reflect the acute parenchyma of liver extent of damage correctly, When the hepatitis patient ALT negative, The ADA positive suggest Acute hepatitis was transformed into chronic hepatitis. The Detection of ADA combined ALT,AST, and GGT has important clinic values on liver disease differential diagnoses