生物
全基因组关联研究
候选基因
遗传学
单核苷酸多态性
遗传关联
SNP公司
表型
多余的
单倍型
基因
基因型
解剖
作者
Wu Peng,Song-Song Xu,Xiao-Die Ren,Feng‐Hua Lv,Xing Long Xie,Yingjun Zhao,Meigen Zhang,Zhiqiang Shen,Yanlin Ren,Lei Gao,Min Shen,Juha Kantanen,Mai‐He Li
摘要
Summary Genome‐wide association studies ( GWAS s) have been widely applied in livestock to identify genes associated with traits of economic interest. Here, we conducted the first GWAS of the supernumerary nipple phenotype in Wadi sheep, a native Chinese sheep breed, based on Ovine Infinium HD SNP BeadChip genotypes in a total of 144 ewes (75 cases with four teats, including two normal and two supernumerary teats, and 69 control cases with two teats). We detected 63 significant SNP s at the chromosome‐wise threshold. Additionally, one candidate region (chr1: 170.723–170.734 Mb) was identified by haplotype‐based association tests, with one SNP (rs413490006) surrounding functional genes BBX and CD 47 on chromosome 1 being commonly identified as significant by the two mentioned analyses. Moreover, Gene Ontology enrichment for the significant SNP s identified by the GWAS analysis was functionally clustered into the categories of receptor activity and synaptic membrane. In addition, pathway mapping revealed four promising pathways (Wnt, oxytocin, MAPK and axon guidance) involved in the development of the supernumerary nipple phenotype. Our results provide novel and important insights into the genetic mechanisms underlying the phenotype of supernumerary nipples in mammals, including humans. These findings may be useful for future breeding and genetics in sheep and other livestock.
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