Effects of Dexmedetomidine on Patients Undergoing Laparoscopic Surgery for Colorectal Cancer

医学 右美托咪定 围手术期 急性肾损伤 腹腔镜手术 肾功能 麻醉 气腹 外科 胃肠病学 泌尿科 腹腔镜检查 内科学 镇静
作者
Wen-Qin Sun,Fengling Li,Xianxue Wang,Hongbo Liu,Min Ki Hong,Dejian Pan,Sijian Wen,Aiguo Zhou
出处
期刊:Journal of Surgical Research [Elsevier BV]
卷期号:267: 687-694 被引量:8
标识
DOI:10.1016/j.jss.2021.06.043
摘要

Background Pneumoperitoneum during laparoscopic surgery has a systemic impact on the renal system and might contribute to acute kidney injury or postoperative renal dysfunction. However, effective preventive strategies are still lacking. We aimed to explore the effects of dexmedetomidine (DEX) on kidney and other organ function in patients undergoing elective laparoscopic surgery for colorectal cancer. Materials and methods Fifty-six patients were randomly enrolled into the Control or DEX group. The DEX group received 1 µg kg−1 DEX intravenously within 10 min followed by a maintenance dose of 0.5 µg kg−1 h−1 infused until 30 min before closing the peritoneum. In the Control group, 0.9% sodium chloride was administered as a placebo. The primary outcome was serum neutrophil gelatinase-associated lipocalin (NGAL) levels reflecting kidney injury. Secondary outcomes included variables reflecting the kidney, intestinal injury and systemic inflammatory response. Results NGAL levels were significantly lower in the DEX group than in the Control group at 1 d and 5 d postoperatively (107.5 ± 55.6 ng mL−1 versus 179.5 ± 78.2 ng mL−1; 70.3 ± 45.8 ng mL−1 versus 135.2 ± 59.6 ng mL−1, P < 0.001), while the BUN and Cr levels showed no differences between the groups. Serum DAO activity was significantly lower in the DEX group patients 24 h after surgery. Moreover, I-FABP levels were markedly lower at 2 h and 24 h postoperatively in the DEX group than in the Control group (P < 0.001). Conclusions Perioperative DEX administration may potentially confer kidney and intestinal protection during laparoscopic surgery for colorectal cancer patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
轻松元绿完成签到 ,获得积分10
1秒前
jkaaa完成签到,获得积分10
2秒前
陈豆豆完成签到 ,获得积分10
3秒前
氯吡格雷完成签到 ,获得积分10
4秒前
zxt完成签到,获得积分10
4秒前
行云流水完成签到,获得积分10
6秒前
阡陌完成签到,获得积分0
8秒前
满意人英完成签到,获得积分10
9秒前
大气夜山完成签到 ,获得积分10
10秒前
Sindy完成签到,获得积分10
13秒前
wdd完成签到 ,获得积分10
15秒前
愉快无心完成签到 ,获得积分10
17秒前
淀粉肠完成签到 ,获得积分10
17秒前
愉快的犀牛完成签到 ,获得积分10
17秒前
18秒前
Zhusy完成签到 ,获得积分10
19秒前
19秒前
lx完成签到,获得积分10
20秒前
我是老大应助科研通管家采纳,获得10
21秒前
Xiaoxiao应助科研通管家采纳,获得10
22秒前
华仔应助科研通管家采纳,获得20
22秒前
22秒前
爆米花应助科研通管家采纳,获得10
22秒前
MQQ完成签到 ,获得积分10
24秒前
络桵完成签到,获得积分10
24秒前
曦夜发布了新的文献求助10
24秒前
狂野未来发布了新的文献求助150
29秒前
闻巷雨完成签到 ,获得积分10
31秒前
hebhm完成签到,获得积分10
31秒前
star完成签到,获得积分10
33秒前
33秒前
活力老少女完成签到 ,获得积分10
33秒前
steven完成签到 ,获得积分10
35秒前
37秒前
perway发布了新的文献求助10
38秒前
科研小郭完成签到,获得积分10
38秒前
五月完成签到 ,获得积分10
39秒前
QQLL完成签到,获得积分10
40秒前
mochen0722完成签到,获得积分10
45秒前
Mr.Ren完成签到,获得积分10
46秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513391
关于积分的说明 11167428
捐赠科研通 3248822
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875116
科研通“疑难数据库(出版商)”最低求助积分说明 804664