免疫系统
免疫学
CD8型
细胞毒性T细胞
人类免疫缺陷病毒(HIV)
T细胞
病毒学
医学
疾病
生物
体外
内科学
遗传学
作者
Aljawharah Alrubayyi,Ester Gea‐Mallorquí,Emma Touizer,Dan Hameiri-Bowen,Jakub Kopycinski,Bethany Charlton,Natasha Fisher-Pearson,Luke Muir,Annachiara Rosa,Chloë Roustan,Christopher Earl,Peter Cherepanov,Pierre Pellegrino,Laura Waters,Fiona Burns,S Kinloch,Tao Dong,Lucy Dorrell,Sarah Rowland‐Jones,Laura E McCoy,Dimitra Peppa
标识
DOI:10.1038/s41467-021-26137-7
摘要
Abstract There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleoprotein are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH.
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