清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

The role of ion channels in the relationship between the immune system and cancer

免疫系统 离子通道 癌细胞 细胞生物学 肿瘤微环境 生物 癌症 化学 免疫学 生物化学 受体 遗传学
作者
Mümin Alper Erdoğan,D’Amora Ugo,Ines Fasolino
出处
期刊:Current Topics in Membranes [Elsevier BV]
卷期号:: 151-198 被引量:7
标识
DOI:10.1016/bs.ctm.2023.09.001
摘要

The immune system is capable of identifying and eliminating cancer, a complicated illness marked by unchecked cellular proliferation. The significance of ion channels in the complex interaction between the immune system and cancer has been clarified by recent studies. Ion channels, which are proteins that control ion flow across cell membranes, have variety of physiological purposes, such as regulating immune cell activity and tumor development. Immune cell surfaces contain ion channels, which have been identified to control immune cell activation, motility, and effector activities. The regulation of immune responses against cancer cells has been linked to a number of ion channels, including potassium, calcium, and chloride channels. As an example, potassium channels are essential for regulating T cell activation and proliferation, which are vital for anti-tumor immunity. Calcium channels play a crucial role when immune cells produce cytotoxic chemicals in order to eliminate cancer cells. Chloride channels also affect immune cell infiltration and invasion into malignancies. Additionally, tumor cells' own expressed ion channels have an impact on their behavior and in the interaction with the immune system. The proliferation, resistance to apoptosis, and immune evasion of cancer cells may all be impacted by changes in ion channel expression and function. Ion channels may also affect the tumor microenvironment by controlling angiogenesis, inflammatory responses, and immune cell infiltration. Ion channel function in the interaction between the immune system and cancer has important implications for cancer treatment. A possible method to improve anti-tumor immune responses and stop tumor development is to target certain ion channels. Small compounds and antibodies are among the ion channel modulators under investigation as possible immunotherapeutics. The complex interaction between ion channels, the immune system, and cancer highlights the significance of these channels for tumor immunity. The development of novel therapeutic strategies for the treatment of cancer will be made possible by unraveling the processes by which ion channels control immune responses and tumor activity. Hence, the main driving idea of the present chapter is trying to understand the possible function of ion channels in the complex crosstalk between cancer and immunoresponse. To this aim, after giving a brief journey of ion channels throughout the history, a classification of the main ion channels involved in cancer disease will be discussed. Finally, the last paragraph will focus on more recently advancements in the use of biomaterials as therapeutic strategy for cancer treatment. The hope is that future research will take advantage of the promising combination of ion channels, immunomodulation and biomaterials filed to provide better solutions in the treatment of cancer disease.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
qianci2009完成签到,获得积分10
3秒前
共享精神应助sh1ro采纳,获得10
13秒前
hahaha完成签到 ,获得积分10
13秒前
19秒前
1437594843完成签到 ,获得积分10
20秒前
清脆钧发布了新的文献求助10
25秒前
雪山飞龙完成签到,获得积分10
29秒前
牵绊完成签到 ,获得积分10
33秒前
坦率雪枫完成签到 ,获得积分10
33秒前
优秀的尔风完成签到,获得积分10
34秒前
满意机器猫完成签到 ,获得积分10
35秒前
情怀应助清脆钧采纳,获得10
40秒前
Alisha完成签到,获得积分10
41秒前
苳苳完成签到 ,获得积分10
1分钟前
1分钟前
清脆钧发布了新的文献求助10
1分钟前
小巧弘文完成签到 ,获得积分10
1分钟前
青山完成签到,获得积分10
1分钟前
清脆钧发布了新的文献求助10
1分钟前
allrubbish完成签到,获得积分10
1分钟前
墨言无殇完成签到 ,获得积分10
1分钟前
传奇3应助清脆钧采纳,获得10
2分钟前
2分钟前
丘比特应助海藏进星辰采纳,获得10
2分钟前
蝎子莱莱xth完成签到,获得积分10
2分钟前
wbh发布了新的文献求助10
2分钟前
辛勤的泽洋完成签到 ,获得积分10
2分钟前
氢锂钠钾铷铯钫完成签到,获得积分10
2分钟前
2分钟前
Square完成签到,获得积分10
2分钟前
2分钟前
2分钟前
树懒完成签到 ,获得积分10
2分钟前
2分钟前
鲑鱼完成签到 ,获得积分10
2分钟前
习月阳完成签到,获得积分10
2分钟前
乒坛巨人完成签到 ,获得积分0
3分钟前
米奇妙妙屋完成签到,获得积分10
3分钟前
liaomr完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990629
求助须知:如何正确求助?哪些是违规求助? 3532220
关于积分的说明 11256552
捐赠科研通 3271057
什么是DOI,文献DOI怎么找? 1805229
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234