孟德尔随机化
全基因组关联研究
精神分裂症(面向对象编程)
重性抑郁障碍
神经影像学
神经科学
单核苷酸多态性
生物
遗传学
医学
遗传变异
精神科
基因
扁桃形结构
基因型
作者
Siying Lin,Haoyang Zhang,Mengling Qi,D.N. Cooper,Yuedong Yang,Yuanhao Yang,Huiying Zhao
出处
期刊:NeuroImage
[Elsevier]
日期:2023-10-01
卷期号:279: 120325-120325
被引量:3
标识
DOI:10.1016/j.neuroimage.2023.120325
摘要
Observational studies consistently disclose brain imaging-derived phenotypes (IDPs) as critical markers for early diagnosis of both brain disorders and cardiovascular diseases. However, it remains unclear about the shared genetic landscape between brain IDPs and the risk of brain disorders and cardiovascular diseases, restricting the applications of potential diagnostic techniques through brain IDPs. Here, we reported genetic correlations and putative causal relationships between 921 brain IDPs, 20 brain disorders and six cardiovascular diseases by leveraging their large-scale genome-wide association study (GWAS) summary statistics. Applications of Mendelian randomization (MR) identified significant putative causal effects of multiple region-specific brain IDPs in relation to the increased risks for amyotrophic lateral sclerosis (ALS), major depressive disorder (MDD), autism spectrum disorder (ASD) and schizophrenia (SCZ). We also found brain IDPs specifically from temporal lobe as a putatively causal consequence of hypertension. The genome-wide colocalization analysis identified three genomic regions in which MDD, ASD and SCZ colocalized with the brain IDPs, and two novel SNPs to be associated with ASD, SCZ, and multiple brain IDPs. Furthermore, we identified a list of candidate genes involved in the shared genetics underlying pairs of brain IDPs and MDD, ASD, SCZ, ALS and hypertension. Our results provide novel insights into the genetic relationships between brain disorders and cardiovascular diseases and brain IDP, which may server as clues for using brain IDPs to predict risks of diseases.
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