In this article, we discuss synchronization in multiplex networks of different layers. Both the topologies and the uncoupled node dynamics in different layers are different. Novel sufficient criteria are derived for intralayer synchronization and interlayer quasisynchronization, in terms of the coupling matrices, the coupling strengths, and the intrinsic function of the uncoupled systems. We also investigate interlayer synchronization of multiplex networks with identical uncoupled node dynamics. Finally, we give some numerical examples to validate the effectiveness of these theoretical results.