Objective We developed a novel method for thyroidectomy using a single‐incision oral vestibular approach. To assess its advantages and disadvantages, we compared the perioperative parameters of this approach with those of transoral three‐incision thyroidectomy and trans‐areolar thyroidectomy. Methods In a study of 136 papillary thyroid carcinoma patients (2016–2018), precise thyroidectomy and neck dissection were conducted. Among them, 52 chose single‐incision oral vestibular approach, 33 chose three‐incision variant, and 51 underwent trans‐areolar thyroidectomy. Perioperative aspects of the transoral single‐incision group were compared with those of transoral three‐incision group, and transthoracic group. Results In the cohort, meticulous tumor level VI lymph node dissection was performed, achieving intended resection extent with one case requiring a switch from transoral to transthoracic approach. No nerve palsy occurred in the transoral group. Thyroidectomy duration varied significantly across groups. Transoral single‐incision had a shorter duration than transoral three‐incision and longer than transthoracic. Minor differences were observed in blood loss and drainage. Perioperative factors like hematoma, infection, hypocalcemia, et al., remained consistent. Notably, no tumor recurrence was observed in this study. Conclusions This new transoral video‐assisted neck surgery (TOVANS) method for thyroidectomy without gas insufflation approach did not increase the surgical complexity compared with the transoral vestibular three‐incision thyroidectomy and the trans‐areolar thyroidectomy. Level of Evidence 3 Laryngoscope , 134:2976–2984, 2024