超分子化学
纳米技术
纳米尺度
转化(遗传学)
纳米线
非共价相互作用
自组装
材料科学
化学
结晶学
氢键
分子
晶体结构
生物化学
有机化学
基因
作者
Long Li,Zhen Li,Ziying Wang,Shuyu Chen,Rongying Liu,Xuyang Xu,Zhi Zhang,Linfei Ye,Yu Ding,Quan Luo,Sheng Cao,Lei Zhang,Anne Imberty,Guosong Chen
出处
期刊:ACS Nano
[American Chemical Society]
日期:2023-07-17
卷期号:17 (15): 15001-15011
被引量:1
标识
DOI:10.1021/acsnano.3c04029
摘要
Precise protein assemblies not only constitute a series of living machineries but also provide an advanced class of biomaterials. Previously, we developed the inducing ligand strategy to generate various fixed protein assemblies, without the formation of noncovalent interactions between proteins. Here, we demonstrated that controlling the symmetry and number of supramolecular interactions introduced on protein surfaces could direct the formation of unspecific interactions between proteins and induce various nanoscale assemblies, including coiling nanowires, nanotubes, and nanosheets, without manipulation of the protein's native surfaces. More importantly, these nanoscale assemblies could spontaneously evolve into more ordered architectures, crystals. We further showed that the transformation from the introduced supramolecular interactions to the interactions formed between proteins was crucial for pathway selection and outcomes of evolution. These findings reveal a transformation mechanism of protein self-assembly that has not been exploited before and may provide an approach to generate complex and transformable biomacromolecular self-assemblies.
科研通智能强力驱动
Strongly Powered by AbleSci AI