小檗碱
异喹啉
化学
生物碱
生物利用度
衍生工具(金融)
药理学
立体化学
生物化学
医学
金融经济学
经济
作者
Elizaveta D. Gladkova,Nicolae Valutsa,С. А. Борисов,Михаил В. Хвостов,O. A. Luzina,Т. Г. Толстикова,Н. Ф. Салахутдинов
出处
期刊:Molbank
[MDPI AG]
日期:2023-02-24
卷期号:2023 (1): M1597-M1597
摘要
Berberine is a phytogenic isoquinoline alkaloid which demonstrates several pharmacological effects, including a hypoglycemic effect. Its medical use is limited by its very low bioavailability. Synthesizing new berberine derivatives might help in overcoming this problem. In this work, we report on the synthesis and biological evaluation of a novel berberine 9-O-derivative. At an oral dose of 25 mg/kg, the compound demonstrated hypoglycemic activity in an oral glucose tolerance test performed using C57BL/6 mice.
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