三氟甲基化
试剂
丁二酰亚胺
三氟甲基
化学
苯胺
组合化学
有机化学
烷基
作者
Hao Liu,Xin He,Zhicheng Chen,Jingchao Zhang,Xinjie Fang,Zhizhong Sun,W. K. Chu
标识
DOI:10.1002/asia.202300039
摘要
Abstract N‐trifluoromethylsuccinimide (NTFS) as a new trifluoromethylation reagent was designed and prepared via Ag−CF 3 , and applied to the direct trifluoromethylation of free aniline, and a series of trifluoromethyl products were obtained with good yields. The practicability of the protocol was verified by a gram‐level experiment and the synthesis of the antiasthmatic drug Mabuterol. In addition, a possible radical mechanism was proposed and verified by related experiments. The protocol provided a new solution for C−H trifluoromethylation of free anilines.
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