NIR light activates upconverting nanoparticles/ZnxMn1-xS core-shell nanoparticles for improved breast cancer treatment

TUC@ZMS targets cancer cells, depletes GSH, and integrates PDT, CDT, and H 2 S gas therapy to eliminate tumors and induce ICD, while H 2 S and Mn 2+ activate cGAS-STING, eliciting systemic anti-tumor immunity, curbing tumor growth and lung metastasis.