Dietary Intake and Gut Microbiome in Chronic Kidney Disease

医学 微生物群 肠道菌群 肾脏疾病 失调 疾病 肠道微生物群 重症监护医学 生物信息学 免疫学 内科学 生物
作者
Julie Ann Kemp,Márcia Ribeiro,Natália A. Borges,L. Cardozo,Denis Fouque,Denise Mafra
出处
期刊:Clinical Journal of The American Society of Nephrology [Lippincott Williams & Wilkins]
标识
DOI:10.2215/cjn.0000000705
摘要

Gut dysbiosis, characterized by an imbalance in the gut microbiota, has emerged as a potential factor influencing chronic kidney disease (CKD) progression. This condition plays a crucial role in the gut-kidney axis, where changes in microbial composition can contribute to systemic inflammation and uremic toxin production and ultimately exacerbate kidney damage. Understanding the dynamics of the gut-kidney axis provides new insights into potential therapeutic strategies to mitigate CKD progression. Diet is the primary driver of gut microbiota composition. Therefore, an approach emphasizing healthy nutritional patterns is recommended for improving overall health, cardiovascular disease, and profoundly altered metabolic patterns in CKD patients. Dietary modifications have been explored as therapeutic strategies targeting the microbiome to improve outcomes in CKD. An emerging therapeutic target is the production of dysmetabolites by the gut microbiota, which may help alleviate uremic and cardiovascular toxicity. Additionally, future research should broaden the scope to include other microorganisms, such as fungi, archaea, and viruses. This expanded focus will enable a more comprehensive understanding of the gut-kidney axis and pave the way for more personalized and effective treatment strategies for CKD patients. This review explores the role of lifestyle, particularly diet, in kidney health, highlights new gut microbiome therapies, and identifies research opportunities in CKD.
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