Ultrasound-Induced In Situ Dopamine Polymerization and Deep Mucosal Penetration for Intraluminal Drug Administration

Prolonging the residence time of drugs in the lumen and propelling them into deep lesions are highly desired for intraluminal drug administration. However, rapid drug efflux caused by dynamic intraluminal contents limits sustained drug concentrations, causing poor pharmaceutical absorption and reduced efficacy. Here, we combined theory and experiments to demonstrate a distinctive drug delivery strategy using clinically available medical ultrasound technology. Through ultrasound-induced