氟利昂
化学
表面改性
催化作用
组合化学
有机化学
物理化学
作者
Qixin Zhou,Jing Wang,Tiancen Bian,Yan Liang,Weikang Yan,Liejin Zhou,Zuxiao Zhang
标识
DOI:10.1021/acs.orglett.4c03338
摘要
We report a visible-light-driven, palladium-catalyzed 1,4-difluoromethylative functionalization of conjugated dienes using chlorodifluoromethane (ClCF2H, Freon-22) as a cost-effective difluoromethyl source. The excited palladium catalyst efficiently reduces the C–Cl bond, which generates a CF2H radical, followed by regioselective SN2' substitution to afford 1,4-difunctionalized products. This versatile, redox-neutral method accommodates diverse nucleophiles and exhibits broad functional group compatibility, making it suitable for late-stage functionalization in drug discovery and offering a direct route to difluoromethylated molecules.
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