生物
计算生物学
线粒体DNA
功能(生物学)
进化生物学
遗传学
基因
作者
Kelvin Yen,Brendan Miller,Hiroshi Kumagai,Ana Silverstein,Pinchas Cohen
标识
DOI:10.1016/j.tig.2024.11.010
摘要
Given the uniqueness of the mitochondria, and the fact that they have their own genome, mitochondrial-derived microproteins (MDPs) are similar to, but different from, nuclear-encoded microproteins. The discovery of an increasing number of microproteins from this organelle and the importance of mitochondria to cellular and organismal health make it a priority to study this novel class of proteins in search of possible therapeutic targets and cures. In this review, we discuss the history of MDP discovery, describe the function of each MDP, and conclude with future goals and techniques to help discover more MDPs.
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