A chitosan N‐ium acetate catalyzed Michael‐aldol‐dehydration‐imino‐Diels‐Alder reaction: One‐pot synthesis of new angular acridine‐fused heterocycles

Abstract A highly efficient domino protocol, Michael‐aldol‐dehydration‐imino‐Diels‐Alder (MAD‐IDA) reaction, that allows the intermediate MAD to combine effectively with the arylamine released from the slow reduction of nitroarene via IDA reaction has been described and several new V‐shaped acridine‐heterocycles have been synthesized after stirring 2‐mercapto‐quinoline‐carbaldehydes/2‐mercapto‐pyridine carbaldehyde/2‐hydroxy‐naphthaldehyde, citral/croton‐aldehyde, and NaSH in chitosan N ‐ium acetate in aqueous ethanol at room temperature. The stereo and regioselectivities of the reaction were confirmed by the 2D NMR experiment and the density functional theory level calculations.