木质素
氨基酸
胶体
化学
球体
有机化学
甲基化
化学工程
生物化学
DNA
物理
天文
工程类
作者
Liheng Chen,Li Tang,Xueqing Qiu,Yanlin Qin
出处
期刊:ACS Sustainable Chemistry & Engineering
[American Chemical Society]
日期:2024-03-08
卷期号:12 (12): 5052-5060
标识
DOI:10.1021/acssuschemeng.4c00779
摘要
This study addresses the challenge of pH-triggered charge reversal nanoparticles (pH-CRNPs), focusing on enhancing their precision and scalability for widespread use. Leveraging the unique properties of lignin, a renewable aromatic macromolecule abundant in plants, we developed lignin nanoparticles (LNPs) through chemical modification with various amino acids followed by methylation in one pot. Methylation partially sealed negative charges, enhancing hydrophobicity, and enabled self-assembly into colloidal spheres with pH responsiveness under alkaline conditions. This innovative approach overcomes the limitations of weak positive charges in conventional LNPs, expanding their application beyond highly acidic tissues. Comprehensive studies explored the relationship between the molecular structure and colloidal sphere stability. Notably, the reagents used exhibited low toxicity, positioning these LNPs as promising candidates for drug delivery with simplified purification steps. This research contributes to the advancement of green synthesis strategies, making LNPs more accessible and efficient for diverse biomedical applications.
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