医学
先天性畸形
怀孕
癫痫
药品
儿科
抗癫痫药
孕早期
丙戊酸
药理学
胎儿
精神科
生物
遗传学
作者
Jacqueline M. Cohen,Silje Alvestad,Elizabeth A. Suarez,Andrea L. Schaffer,Randi Selmer,Alys Havard,Brian T. Bateman,Carolyn E. Cesta,Helga Zoëga,Ingvild Odsbu,Krista F. Huybrechts,Lars J. Kjerpeseth,Loreen Straub,Maarit K. Leinonen,Marte‐Helene Bjørk,Mette Nørgaard,Mika Gissler,Sinna Pilgaard Ulrichsen,Sonia Hernández–Dı́az,Torbjörn Tomson
出处
期刊:Neurology
[Lippincott Williams & Wilkins]
日期:2023-12-26
卷期号:102 (2)
被引量:11
标识
DOI:10.1212/wnl.0000000000207996
摘要
Valproate should be avoided in pregnancy, but it is the most effective drug for generalized epilepsies. Alternative treatment may require combinations of other drugs. Our objectives were to describe first trimester use of antiseizure medication (ASM) combinations that are relevant alternatives to valproate and determine whether specific combinations were associated with a lower risk of major congenital malformations (MCM) compared with valproate monotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI