Multifunctional drug delivery nanoparticles based on MIL-100 (Fe) for photoacoustic imaging-guided synergistic chemodynamic/chemo/photothermal breast cancer therapy

Compared with visceral cancers, breast cancer is epidermal and can be efficiently eliminated by photoacoustic imaging (PAI)-guided cancer therapy. In this study, we developed multifunctional nanoparticles (DMTH NPs) by loading doxorubicin (DOX) into MIL-100, which were modified with tannic acid (TA) and hyaluronic acid (HA) using a simple and convenient method. MIL-100 (Fe) in DMTH NPs allowed for chemodynamic therapy by converting endogenous hydrogen peroxide (H2O2) into •OH through a Fenton-like reaction to assist DOX in killing cancer cells. DMTH NPs had high DOX loading efficiency for chemotherapeutic function and had the ability for photoacoustic imaging (PAI) and photothermal therapy (PTT) after being modified by TA. Specifically, DMTH NPs targeted tumors and had low toxicity in vivo. Ultimately, the released DOX and •OH cooperated in killing MCF-7 cells effectively in vitro. The enhanced and precise breast cancer treatment was achieved using a PAI-guided chemodynamic/chemo/photothermal synergistic therapy under laser irradiation in vivo. Overall, this work presented an innovative strategy for designing multifunctional nanoparticles for effective imaging-guided combination therapies to combat breast cancer.