CXCL2型
分泌物
再生(生物学)
计算机科学
免疫学
生物
医学
炎症
细胞生物学
趋化因子
内科学
趋化因子受体
作者
Weiwei Lin,Qiwen Li,L Liu,Qian Wang,Danting Zhang,Feiyu Wang,Ruoshi Xu,Yi Fan,Malcolm Xing,Chenchen Zhou,Quan Yuan
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2024-05-17
卷期号:10 (20)
标识
DOI:10.1126/sciadv.adl6343
摘要
Trauma rapidly mobilizes the immune response of surrounding tissues and activates regeneration program. Manipulating immune response to promote tissue regeneration shows a broad application prospect. However, the understanding of bone healing dynamics at cellular level remains limited. Here, we characterize the landscape of immune cells after alveolar bone injury and reveal a pivotal role of infiltrating natural killer T (NKT) cells. We observe a rapid increase in NKT cells after injury, which inhibit osteogenic differentiation of mesenchymal stem cells (MSCs) and impair alveolar bone healing. Cxcl2 is up-regulated in NKT cells after injury. Systemic administration of CXCL2-neutralizing antibody or genetic deletion of Cxcl2 improves the bone healing process. In addition, we fabricate a gelatin-based porous hydrogel to deliver NK1.1 depletion antibody, which successfully promotes alveolar bone healing. In summary, our study highlights the importance of NKT cells in the early stage of bone healing and provides a potential therapeutic strategy for accelerating bone regeneration.
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