局灶节段性肾小球硬化
蛋白尿
医学
肾病
内分泌学
内科学
促炎细胞因子
肾病综合征
细胞因子
肾
炎症
作者
Narisa Futrakul,Tasanee Panichakul,Punnee Butthep,Prasit Futrakul,Pim Jetanalin,Suthiluk Patumraj,Prasong Siriviriyakul
出处
期刊:PubMed
日期:2004-01-01
卷期号:31 (4): 267-72
被引量:16
摘要
A persistent proteinuria is commonly observed in nephrotic patient with focal segmental glomerulosclerosis (FSGS) under treatment with prednisolone+/-cyclophosphamide or with vasodilators (ACEI+AII receptor antagonist, calcium channel blocker and antiplatelet agent). Fourteen such patients with persistent proteinuria were subject to be treated with Ganoderma lucidum. Initial study revealed an enhanced endothelial cell cytotoxicity induced by patient's serum, and an altered immunocirculatory balance with predominant proinflammatory cytokine TNF alpha activity in the presence of defective anti-inflammatory cytokine interleukin-10. Treatment with Ganoderma lucidum suppressed endothelial cell cytotoxicity, restored immunocirculatory balance and successfully suppressed proteinuria in all of these 14 patients.
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