压力(语言学)
战斗或逃跑反应
神经科学
心理学
生物
哲学
遗传学
语言学
基因
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2019-05-02
卷期号:364 (6439): 447.16-449
标识
DOI:10.1126/science.364.6439.447-p
摘要
Structural Biology
During translation, regulation of protein synthesis by phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is a common consequence of diverse stress stimuli, which leads to reprogramming of gene expression. This process, known as the integrated stress response, is one of the most fundamental mechanisms of translational control conserved throughout eukaryotes. It is also a promising therapeutic target in neurodegenerative diseases and traumatic brain injury. Kashiwagi et al. report the cryo–electron microscopy and crystal structures and Kenner et al. report the cryo–electron microscopy structure of the guanine nucleotide exchange factor eIF2B in complex with eIF2 or phosphorylated eIF2. The structures of the eIF2•eIF2B complex reveal that the single phosphorylation modification on eIF2 changes how eIF2 binds to eIF2B and locks this enzyme into an inhibited complex.
Science , this issue p. [495][1], p. [491][2]
[1]: /lookup/doi/10.1126/science.aaw4104
[2]: /lookup/doi/10.1126/science.aaw2922
科研通智能强力驱动
Strongly Powered by AbleSci AI