动力学分辨率
化学
钌
还原胺化
催化作用
对映选择合成
胺化
组合化学
转移加氢
基质(水族馆)
有机化学
海洋学
地质学
作者
Donghui Guo,Jianwei Zhang,Bei Zhang,Jian Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-09-24
卷期号:20 (19): 6284-6288
被引量:28
标识
DOI:10.1021/acs.orglett.8b02785
摘要
The unprecedented ruthenium-catalyzed atropoenantioselective reductive amination of aldehydes with alkylamines via a cascade transfer hydrogenation and dynamic kinetic resolution strategy is described. This protocol features broad substrate scope and good functional group tolerance and allows the rapid assembly of axially chiral biaryls in good to high yields with high to excellent enantioselectivities. In addition, such structural motifs may have potential applications in enantioselective catalysis as chiral ligands or catalysts.
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